Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi

被引：61
作者：
Haraguchi, H [1 ]
Oike, S [1 ]
Muroi, H [1 ]
Kubo, I [1 ]
机构：
[1] UNIV CALIF BERKELEY, DEPT ENVIRONM SCI POLICY & MANAGEMENT, BERKELEY, CA 94720 USA
来源：
PLANTA MEDICA | 1996年 / 62卷 / 02期
关键词：
Podocarpus nagi; Podocarpaceae; totarol; antimicrobial action; respiratory inhibition; electron transport; Pseudomonas aeruginosa;
D O I：
10.1055/s-2006-957832
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The antimicrobial mechanism of totarol was studied using Pseudomonas aeruginosa IFO 3080. This diterpene inhibited oxygen consumption and respiratory-driven proton translocation in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome c reductase was inhibited by totarol while cytochrome c oxidase was not. NADH-DPIP reductase and NADH-CoQ reductase were also inhibited. The site of respiratory inhibition of totarol was thought to be near CoQ in the bacterial electron transport chain.
引用
收藏
页码：122 / 125
页数：4
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