Easy and efficient one-pot synthesis of pyrazolo[1,5-c]quinazolines under mild copper-catalyzed conditions

被引：32
作者：
Yang, Xiaobo [1 ]
Jin, Yibao [2 ]
Liu, Hongxia [2 ]
Jiang, Yuyang [2 ]
Fu, Hua [1 ,2 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Key Lab Chem Biol Guangdong Prov, Grad Sch Shenzhen, Shenzhen 518057, Peoples R China
来源：
RSC ADVANCES | 2012年 / 2卷 / 29期
基金：
中国国家自然科学基金;
关键词：
C-N; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; COUPLING REACTIONS; CASCADE SYNTHESIS; DOMINO SYNTHESIS; DERIVATIVES; INHIBITORS; QUINAZOLINE; ULLMANN;
D O I：
10.1039/c2ra21929h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An easy and efficient method has been developed for the synthesis of pyrazolo[1,5-c]quinazolines via one-pot two-step reactions of readily available substituted 1-(2-halophenyl)-3-akylprop-2-yn-1-ones, hydrazine hydrochloride and amidine hydrochlorides under mild conditions, and the corresponding pyrazolo[1,5-c]quinazolines were obtained in good to excellent yields. The novel method affords a new strategy for the construction of diverse and useful poly N-heterocyclic compounds.
引用
收藏
页码：11061 / 11066
页数：6
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