Adult Neural Stem Cells Bridge Their Niche

被引：276
|
作者：
Fuentealba, Luis C. [1 ,2 ]
Obernier, Kirsten [1 ,2 ]
Alvarez-Buylla, Arturo [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Inst Regenerat Med, San Francisco, CA 94143 USA
来源：
CELL STEM CELL | 2012年 / 10卷 / 06期
基金：
美国国家卫生研究院;
关键词：
EPIDERMAL-GROWTH-FACTOR; LONG-TERM POTENTIATION; SUBVENTRICULAR ZONE; VASCULAR NICHE; SONIC HEDGEHOG; HIPPOCAMPAL NEUROGENESIS; VENTRICULAR ZONE; ANALYSIS REVEALS; PRIMARY CILIA; SELF-RENEWAL;
D O I：
10.1016/j.stem.2012.05.012
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), with signaling pathways that control the behavior of NSCs. NSCs in the adult brain stretch into physiologically distinct compartments of their niche. We propose how adult NSCs' morphology may allow these cells to integrate multiple signaling pathways arising from unique locations of their niche.
引用
收藏
页码：698 / 708
页数：11
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