Mechanisms of radiation-induced lymphopenia and therapeutic impact

被引：13

作者：

Cesaire, Mathieu ^{[1
]}

Le Mauff, Brigitte ^{[2
,3
]}

Rambeau, Audrey ^{[1
]}

Toutirais, Olivier ^{[2
,3
]}

Thariat, Juliette ^{[1
,4
,5
]}

机构：

[1] Ctr Francois Baclesse ARCHADE, Dept Radiotherapie, 3 Ave Gen Harris, F-14000 Caen, France

[2] Normandie Univ, UNICAEN, Serine Proteases & Physiopathol Unite Neurovasc, Inserm U919, Caen, France

[3] Univ Hosp Caen, Dept Immunol, Caen, France

[4] Lab Phys Corpusculaire, IN2P3, ENSICAEN UMR6534, Caen, France

[5] Normandie Univ, UNICAEN, Caen, France

来源：

BULLETIN DU CANCER | 2020年 / 107卷 / 7-8期

关键词：

Radiation therapy; Lymphopenia; Immunotherapy; Prognosis; HUMAN LYMPHOCYTES-T; BLOOD-LYMPHOCYTES; SURVIVAL OUTCOMES; SKIN FIBROBLASTS; PERIPHERAL-BLOOD; PROTON; CANCER; CELLS; RADIOSENSITIVITY; RADIOTHERAPY;

D O I：

10.1016/j.bulcan.2020.04.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation induced lymphopenia is frequent and can be severe and durable. Although lymphocytes hove long been known as highly radiosensitive cells, it is poorly characterized. Radiation-induced lymphopenia seems to affect lymphocyte subpopulations differently and seems to be influenced by radiation modalities. The depth and duration of lymphopenia depend on the location of the irradiation and the volumes of treatment. Importantly, radiation-induced lymphopenia has been associated with poorer prognosis in several tumor types. The knowledge about radiation-induced lymphopenia might lead to a rethinking of the modalities of radiotherapy and new approaches to restore lymphocytes counts.

引用

页码：813 / 822

页数：10

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