Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients

被引：78

作者：

Bellesi, Silvia ^{[1
]}

Metafuni, Elisabetta ^{[1
]}

Hohaus, Stefan ^{[1
,2
]}

Maiolo, Elena ^{[1
]}

Marchionni, Federica ^{[1
]}

D'Innocenzo, Simone ^{[1
]}

La Sorda, Marilena ^{[3
]}

Ferraironi, Manuela ^{[3
]}

Ramundo, Francesco ^{[2
]}

Fantoni, Massimo ^{[3
,4
]}

Murri, Rita ^{[3
,4
]}

Cingolani, Antonella ^{[3
,4
]}

Sica, Simona ^{[1
,2
]}

Gasbarrini, Antonio ^{[5
]}

Sanguinetti, Maurizio ^{[3
,6
]}

Chiusolo, Patrizia ^{[1
,2
]}

De Stefano, Valerio ^{[1
,2
]}

机构：

[1] Fdn Policlin Univ A Gemelli, IRCCS, Dipartimento Diagnost Immagini, Radioterapia Oncol & Ematol, Lgo A Gemelli 8, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dipartimento Sci Radiol & Ematol, Sez Ematol, Rome, Italy

[3] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab & Infettivol, Rome, Italy

[4] Univ Cattolica Sacro Cuore, Dipartimento Sicurezza & Bioet, Sez Malattie Infett, Rome, Italy

[5] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, IRCCS, Dipartimento Sci Med & Chirurg, Rome, Italy

[6] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnol Base Clin Intensivol &, Rome, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 191卷 / 02期

关键词：

COVID-19; CD95 (Fas); PD-1; apoptosis; exhaustion; APOPTOSIS; CELLS;

D O I：

10.1111/bjh.17034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A low count of CD4(+)and CD8(+)lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4(+)T and CD8(+)T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4(+)cells correlated with lower CD4(+)counts. A higher expression of CD95 in CD4(+)and CD8(+)lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.

引用

页码：207 / 211

页数：5

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