Polymorphisms of cytokine and innate immunity genes and GVHD

被引：50

作者：

Dickinson, A. M. ^{[1
]}

Holler, E. ^{[2
]}

机构：

[1] Univ Newcastle, Sch Med, Inst Cellular Med, Sch Clin & Lab Sci, Newcastle Upon Tyne, Tyne & Wear, England

[2] Univ Regensburg, Med Ctr, Dept Haematol Oncol, D-8400 Regensburg, Germany

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2008年 / 21卷 / 02期

关键词：

haematopoietic stem-cell transplantation; non-HLA genetics; graft-versus-host disease;

D O I：

10.1016/j.beha.2008.03.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the last 10 years, non-HLA genotypes have been investigated for their potential roles in the occurrence and severity of graft-versus-host disease (GVHD) as well as for their contribution to overall transplant-related mortality, infectious episodes, and overall survival. This chapter will review the latest results of cytokine gene polymorphisms between patient and donor which may cause the production of high or low levels of cytokines during the three-stage process of the GVHD 'cytokine storm'. More recent investigations into innate immunity and the interaction with subsequent downstream cytokine production and ultimate tissue damage are discussed. The potential of these non-HLA genetics to aid in predicting GVHD and post-transplant survival and the relevance of this information to the clinic are reviewed.

引用

页码：149 / 164

页数：16

共 110 条

[1]

ABRAHAM LJ, 1993, CLIN EXP IMMUNOL, V92, P14

[2] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[3] Endothelium-derived toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs [J].

Andonegui, G ;

Bonder, CS ;

Green, F ;

Mullaly, SC ;

Zbytnuik, L ;

Raharjo, E ;

Kubes, P .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (07) :1011-1020

[4] RECOMBINANT HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE TREATMENT OF STEROID-RESISTANT GRAFT-VERSUS-HOST DISEASE [J].

ANTIN, JH ;

WEINSTEIN, HJ ;

GUINAN, EC ;

MCCARTHY, P ;

BIERER, BE ;

GILLILAND, DG ;

PARSONS, SK ;

BALLEN, KK ;

RIMM, IJ ;

FALZARANO, G ;

BLOEDOW, DC ;

ABATE, L ;

LEBSACK, M ;

BURAKOFF, SJ ;

FERRARA, JLM .

BLOOD, 1994, 84 (04) :1342-1348

[5] Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation [J].

Antin, JH ;

Weisdorf, D ;

Neuberg, D ;

Nicklow, R ;

Clouthier, S ;

Lee, SJ ;

Alyea, E ;

McGarigle, C ;

Blazar, BR ;

Sonis, S ;

Soiffer, RJ ;

Ferrara, JLM .

BLOOD, 2002, 100 (10) :3479-3483

[6] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine [J].

Asea, A ;

Kraeft, SK ;

Kurt-Jones, EA ;

Stevenson, MA ;

Chen, LB ;

Finberg, RW ;

Koo, GC ;

Calderwood, SK .

NATURE MEDICINE, 2000, 6 (04) :435-442

[7] TGF-β in allogeneic stem cell transplantation:: friend or foe? [J].

Banovic, T ;

MacDonald, KPA ;

Morris, ES ;

Rowe, V ;

Kuns, R ;

Don, A ;

Kelly, J ;

Ledbetter, S ;

Clouston, AD ;

Hill, GR .

BLOOD, 2005, 106 (06) :2206-2214

[8] Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway [J].

Basu, S ;

Binder, RJ ;

Suto, R ;

Anderson, KM ;

Srivastava, PK .

INTERNATIONAL IMMUNOLOGY, 2000, 12 (11) :1539-1546

[9] Association of TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic stem cell transplantation [J].

Bettens, Florence ;

Passweg, Jakob ;

Gratwohl, Alois ;

Chalandon, Yves ;

Helg, Claudine ;

Chapuis, Bernard ;

Schanz, Urs ;

Libura, Jolanta ;

Roosnek, Eddy ;

Tiercy, Jean-Marie .

TRANSPLANTATION, 2006, 81 (09) :1261-1267

[10]

Bogunia-Kubik K, 2005, HAEMATOLOGICA, V90, P425

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