Determinants and trends in perinatal human immunodeficiency virus type 1 (HIV-1) transmission in the metropolitan area of Belo Horizonte, Brazil: 1998-2005

被引：20

作者：

Kakehasi, Fabiana Maria

Pinto, Jorge A. ^{[1
]}

de Castro Romanelli, Roberta Maia

Carneiro, Mariangela ^{[3
]}

Cardoso, Carolina Silva

Teatini Tavares, Maria do Carmo ^{[4
]}

Melo, Victor Hugo ^{[2
]}

Lopes Pessoa de Aguiar, Regina Amelia ^{[2
]}

机构：

[1] Univ Fed Minas Gerais, Dept Pediat, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Obstet & Ginecol, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, BR-30130100 Belo Horizonte, MG, Brazil

[4] Ctr Treinamento & Referencia Doencas Infecciosas, Secretaria Saude Prefeitura Municipal Belo Horizo, Belo Horizonte, MG, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2008年 / 103卷 / 04期

关键词：

HIV-1; vertical transmission; pregnant women; antiretroviral therapy;

D O I：

10.1590/S0074-02762008000400007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Significant decrease in human immunodeficiency virus type 1 (HIV-1) vertical transmission has been observed worldwide in centers where interventions such as antiretroviral therapy ( ART), elective cesarean section, and avoidance of breastfeeding have been implemented. This prospective cohort study aimed to assess the determinants of and the temporal trends in HIV-1 vertical transmission in the metropolitan area of Belo Horizonte, Brazil from January 1998 to December 2005. The rate of HIV-1 vertical transmission decreased from 20% in 1998 to 3% in 2005. This decline was associated with increased use of more complex ART regimens during pregnancy. Multivariate analysis restricted to clinical variables demonstrated that non ART, neonatal respiratory distress/sepsis and breastfeeding were independently associated with HIV-1 vertical transmission. When laboratory parameters were included in the model, high maternal viral load and non maternal ART were associated with HIV-1 vertical transmission. The results from this study confirm the impact of ART in the reduction of HIV-1 vertical transmission and indicate the need for improvement in the care and monitoring of mother and infant pairs affected by HIV-1.

引用

页码：351 / 357

页数：7

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