An inflammatory transcriptional switch

被引：1

作者：

Murtaugh, L. Charles ^{[1
]}

Macdonald, Raymond J. ^{[2
,3
]}

机构：

[1] Univ Utah, Dept Human Genet, Salt Lake City, UT 84112 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

NATURE | 2018年 / 554卷 / 7693期

关键词：

NR5A2; DIFFERENTIATION;

D O I：

10.1038/d41586-018-01262-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mouse pancreas adopts a pre-inflammatory state in response to a chemical injury or the loss of one copy of the gene Nr5a2. This state might predispose mice, and possibly humans, to pancreatitis and pancreatic cancer.

引用

页码：470 / +

页数：4

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