Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population

被引:3
作者
Zhang, Chan [1 ]
Ding, Heng [2 ]
Cheng, Yujing [1 ]
Chen, Wanlu [1 ]
Li, Qi [1 ]
Li, Qing [1 ]
Dai, Run [1 ]
Luo, Manlin [3 ]
机构
[1] Kunming Univ Sci & Technol, Affiliated Hosp, Peoples Hosp Yunnan Prov 1, Dept Blood Transfus, Kunming 650032, Yunnan, Peoples R China
[2] Honghe Ctr Blood Stn, Mengzi 661100, Yunnan, Peoples R China
[3] Second Peoples Hosp Yunnan Prov, Dept Blood Transfus, Kunming 650032, Yunnan, Peoples R China
关键词
drug addiction; ALDH2; single nucleotide polymorphisms (SNPs); case-control study; association study; ALCOHOL-CONSUMPTION; ALDEHYDE DEHYDROGENASE-2; GLU504LYS POLYMORPHISM; CANCER; SENSITIVITY; DEPENDENCE; RS886205; RISK;
D O I
10.18632/oncotarget.14354
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We investigated the association between single nucleotide polymorphisms (SNPs) in ALDH2, which has been associated with alcohol dependence and several types of diseases, and the risk of drug addiction in a Chinese Han population. In a case-control study that included 692 cases and 700 healthy controls, eight SNPs in ALDH2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. We determined that rs671 is significantly associated with a 1.551-fold increased drug addiction risk (95% CI = 1.263-1.903; p < 0.001). In the genetic model analysis, we found that rs671 is associated with an increased risk of drug addiction under additive, dominant and recessive models (p < 0.001), while rs886205, rs441 and rs4646778 displayed a decreased drug addiction risk under additive and recessive model, respectively (p < 0.05). SNP rs671 remained significant after Bonferroni correction (p < 0.00125). Additionally, we observed that haplotype "GTCAC" was associated with increased drug addiction risk (OR = 1.668; 95% CI, 1.328-2.094, p < 0.001); in contrast, "ATCGC" was a protective haplotype for drug addiction risk (OR = 0.444; 95% CI, 0.281-0.704, p < 0.001). Our findings showed that ALDH2 polymorphisms are significantly associated with the risk of drug addiction in the Chinese Han population.
引用
收藏
页码:8597 / 8603
页数:7
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