Isothermal titration calorimetry in membrane protein research

被引：35

作者：

Draczkowski, Piotr ^{[1
]}

Matosiuk, Dariusz ^{[1
]}

Jozwiak, Krzysztof ^{[1
]}

机构：

[1] Med Univ Lublin, Fac Pharm, PL-20093 Lublin, Poland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2014年 / 87卷

关键词：

Thermodynamics; Ionotropic receptors; G-protein coupled receptors; Transporters; Drug-target interactions; RESPONDING TRANSCRIPTIONAL REGULATOR; MULTIDRUG TRANSPORTER EMRE; LIGAND-BINDING; CRYSTAL-STRUCTURE; PARATHYROID-HORMONE; MOLECULAR-BASIS; VANT HOFF; SIGNIFICANT DISCREPANCIES; THERMODYNAMIC PARAMETERS; 3-DIMENSIONAL STRUCTURE;

D O I：

10.1016/j.jpba.2013.09.003

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Isothermal titration calorimetry is a versatile method to characterize energetics of intermolecular reactions and in particular interactions between drug molecules and their macromolecular targets. The assay is widely used in medicinal chemistry to quantification and characterization of molecular mechanisms of these interactions. The article reviews applications of the method to study ligand interactions with various classes of embedded membrane proteins. These proteins constitute very important fraction of macromolecular targets for medicinal compounds used in current therapies and recently emerged for detailed structural, functional and biochemical characterization of their interactions with drug molecules. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：313 / 325

页数：13

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