SN2′ Reaction of Allylic Difluorides with Lithium Amides and Thiolates

被引：59

作者：

Bergeron, Maxime ^{[1
]}

Guyader, David ^{[1
]}

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, Canada Res Chair Organ & Med Chem, Quebec City, PQ G1V 0A6, Canada

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 23期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

CONCISE SYNTHESIS; ORGANOLITHIUM REAGENTS; FLUORINE; PHARMACEUTICALS; ACTIVATION; INHIBITORS; AMINATION; CHEMISTRY; OXIDASE;

D O I：

10.1021/ol302802r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of monofluoroalkenes using an S(N)2' reaction of lithium amides derived from aromatic amines or lithium thiolates with 3,3-difluoropropenes is reported. This transformation features the use of fluoride as a leaving group.

引用

页码：5888 / 5891

页数：4

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