Dramatic Solvent Effect in the One-Pot Synthesis of Substituted Ureas Directly from Primary Alcohols Using the Combined Reagent of Iodobenzene Dichloride and Sodium Azide in Ethyl Acetate

被引：11

作者：

Zhang, Chi ^{[1
]}

Wang, Wei-Kun ^{[1
]}

He, Tian ^{[1
]}

机构：

[1] Nankai Univ, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 19期

基金：

中国国家自然科学基金;

关键词：

alcohols; amines; oxidation; iodobenzene dichloride; hypervalent iodine; POLYVALENT IODINE COMPOUNDS; UNSYMMETRICAL UREAS; CARBAMOYL AZIDES; PRIMARY AMINES; S; S-DIMETHYL DITHIOCARBONATE; TETRASUBSTITUTED UREAS; SECONDARY ALCOHOLS; CHEMISTRY; COMBINATION; DERIVATIVES;

D O I：

10.1055/s-0032-1316745

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient and practical method for the synthesis of substituted ureas directly from various primary alcohols and amines has been developed. This method is based on the finding that the use of ethyl acetate as the solvent can result in an improved efficiency of the transformation of various primary alcohols to their corresponding carbamoyl azides with the combined reagent of iodobenzene dichloride (PhICl2) and sodium azide.

引用

页码：3006 / 3014

页数：9

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