Sulfamic acid: an efficient and recyclable solid acid catalyst for the synthesis of 4,5-dihydropyrrolo[1,2-a]quinoxalines

被引：27

作者：

Kamal, Ahmed ^{[1
]}

Babu, Korrapati Suresh ^{[1
]}

Hussaini, S. M. Ali ^{[1
]}

Srikanth, P. S. ^{[1
]}

Balakrishna, Moku ^{[1
]}

Alarifi, Abdullah ^{[2
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India

[2] King Saud Univ, Coll Sci, Dept Chem, Catalyt Chem Res Chair, Riyadh 11451, Saudi Arabia

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 31期

关键词：

Dihydropyrrolo[1,2-a]quinoxalines; Sulfamic acid; Reusability; Cytotoxicity; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; ANTICANCER AGENTS; MOLECULAR DOCKING; DERIVATIVES; INHIBITORS; QUINOXALINES; APOPTOSIS; BINDING;

D O I：

10.1016/j.tetlet.2015.06.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, and eco-friendly method has been developed for the synthesis of 4,5-dihydropyrrolo[1,2-a]quinoxalines using sulfamic acid (H2NSO3H, SA), a green and recyclable catalyst in water. The method employs readily available catalysts and is notable for short reaction time, operational simplicity, and high yields. The catalyst can be recovered and reused without loss of activity and more importantly, the reaction uses water as a solvent which is naturally abundant and environmentally benign. Moreover, the synthesized compounds were screened for their cytotoxic potential against two human cancer cell lines. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4619 / 4622

页数：4

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