Advances in Base-Metal Catalysis: Development of a Screening Platform for Nickel-Catalyzed Borylations of Aryl (Pseudo)halides with B2(OH)4

被引：31

作者：

Coombs, John R. ^{[1
]}

Green, Rebecca A. ^{[1
]}

Roberts, Frederick ^{[1
]}

Simmons, Eric M. ^{[1
]}

Stevens, Jason M. ^{[1
]}

Wisniewski, Steven R. ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Chem & Synthet Dev, One Squibb Dr, New Brunswick, NJ 08903 USA

来源：

ORGANOMETALLICS | 2019年 / 38卷 / 01期

关键词：

PRACTICAL SYNTHESIS; PALLADIUM; HALIDES; PD; REMOVAL; ART;

D O I：

10.1021/acs.organomet.8b00307

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Investigations into nickel-catalyzed borylation reactions have led to the development of an experimental design of 24 reaction conditions for rapid lead identification. A case study on the borylation of a model aryl bromide with B-2(OH)(4) prompted a series of mechanistic and stability studies to better understand the catalytic cycle and factors that affect robustness. HTEx was employed to study the effect of a series of scavengers on the remediation of nickel from the reaction stream. These combined results have generated an increased understanding of nickel-catalyzed borylation reactions and set the stage for their expanded use in process chemistry.

引用

页码：157 / 166

页数：10

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