Enantioselective Palladium-Catalyzed Heck-Heck Cascade Reactions: Ready Access to the Tetracyclic Core of Lycorane Alkaloids

被引：20
作者：
Coya, Estibaliz [1 ]
Sotomayor, Nuria [1 ]
Lete, Esther [1 ]
机构：
[1] Univ Basque Country, Euskal Herriko Unibertsitatea, Fac Ciencia & Tecnol, Dept Quim Organ 2, Bilbao 48080, Spain
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 14-15期
关键词：
alkaloids; asymmetric catalysis; domino reactions; Heck reaction; palladium; ASYMMETRIC HECK; POLYENE CYCLIZATIONS; NITROALLYL ACETATES; DIRECT ARYLATION; AMARYLLIDACEAE; LYCORINE;
D O I：
10.1002/adsc.201500431
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A rapid and efficient access to a wide variety of enantiomerically enriched C-11b substituted lycorane analogues can be achieved via a catalytic asymmetric Heck-Heck 6-exo/6-endo cascade reaction in the presence of (R)-BINAP.
引用
收藏
页码：3206 / 3214
页数：9
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