COMPARISON OF THE TOXICITY OF FLUORIDATION COMPOUNDS IN THE NEMATODE CAENORHABDITIS ELEGANS

被引：15

作者：

Rice, Julie R. ^{[1
]}

Boyd, Windy A. ^{[1
]}

Chandra, Dave ^{[2
]}

Smith, Marjolein V. ^{[3
]}

Den Besten, Pamela K. ^{[2
]}

Freedman, Jonathan H. ^{[4
]}

机构：

[1] NIEHS, Biomol Screening Branch, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC 27709 USA

[2] Univ Calif San Francisco, Dept Orofacial Sci, UCSF Sch Dent, San Francisco, CA 94143 USA

[3] SRA Int, Res Triangle Pk, NC USA

[4] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2014年 / 33卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Caenorhabditis elegans; Toxicity testing; Fluoride toxicity; Drinking water; Silicofluoride; WATER; MODEL; LEAD;

D O I：

10.1002/etc.2394

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Fluorides are commonly added to drinking water in the United States to decrease the incidence of dental caries. Silicofluorides, such as sodium hexafluorosilicate (Na2SiF6) and fluorosilicic acid (H2SiF6), are mainly used for fluoridation, although fluoride salts such as sodium fluoride (NaF) are also used. Interestingly, only the toxicity of NaF has been examined and not that of the more often used silicofluorides. In the present study, the toxicities of NaF, Na2SiF6, and H2SiF6 were compared. The toxicity of these fluorides on the growth, feeding, and reproduction in the alternative toxicological testing organism Caenorhabditis elegans was examined. Exposure to these compounds produced classic concentration-response toxicity profiles. Although the effects of the fluoride compounds varied among the 3 biological endpoints, no differences were found between the 3 compounds, relative to the fluoride ion concentration, in any of the assays. This suggests that silicofluorides have similar toxicity to NaF. Environ Toxicol Chem 2013;33:82-88. (c) 2013 SETAC

引用

页码：82 / 88

页数：7

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