Occult lymph node metastasis in laryngeal squamous cell carcinoma: Therapeutic and prognostic impact

被引：31
作者：
Mnejja, M. [1 ]
Hammami, B. [1 ]
Bougacha, L. [1 ]
Chakroun, A. [1 ]
Charfeddine, I. [1 ]
Khabir, A. [2 ]
Boudaoura, T. [2 ]
Ghorbel, A. [1 ]
机构：
[1] CHU Habib Bourguiba, Serv ORL & Chirurg Cervicofaciale, Sfax 3029, Tunisia
[2] CHU Habib Bourguiba, Serv Anat Pathol, Sfax 3029, Tunisia
来源：
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES | 2010年 / 127卷 / 05期
关键词：
Squanious cell carcinoma; Larynx; Occult lymph node metastasis; Selective neck dissection; SELECTIVE NECK DISSECTION; SUBLEVEL IIB; LEVEL-IIB; ROUTINE INCLUSION; N0; NECK; IV; PREVALENCE; MANAGEMENT; CANCER; HEAD;
D O I：
10.1016/j.anorl.2010.07.011
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objectives: To assess the incidence and impact on treatment and prognosis of occult lymph node metastasis in laryngeal cancer. Patients and methods: A retrospective study was performed on 164 patients treated for laryngeal cancer, initially classified as N0, with cervical lymph node dissection. Results: Occult metastases were found in 41 neck specimens (12.5%) from 32 patients (19.5%). Involvement per neck level was: 7% level IIa, 2.4% IIb, 4.2% III and 2.7% IV. Lymph node involvement was significantly increased in case of T3T4 tumor or invasion of the pre-epiglottic space or cartilage. Survival was significantly influenced by pN status (pN- = 12 years, vs pN+ = 9 years; P = 0.006). Conclusion: Level IIb or IV involvement is rare. Superselective neck dissection (IIa, Ill) seems to be indicated in T1T2 N0 tumor. In case of advanced tumor or pre-epigtottic space or cartilage invasion, functional neck dissection is mandatory. (C) 2010 Published by Elsevier Masson SAS.
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页码：173 / 176
页数：4
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