Transcriptional and epigenetic regulation of human microRNAs

被引：103
作者：
Wang, Zifeng [1 ,2 ]
Yao, Hong [3 ,4 ]
Lin, Sheng [5 ]
Zhu, Xiao [6 ]
Shen, Zan [7 ]
Lu, Gang [1 ,2 ]
Poon, Wai Sang [1 ,2 ]
Xie, Dan [8 ]
Lin, Marie Chia-mi [1 ,2 ]
Kung, Hsiang-fu [3 ,4 ]
机构：
[1] Chinese Univ Hong Kong, Brain Tumour Ctr, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Surg, Div Neurosurg, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, State Key Lab Oncol South China, Shatin, Hong Kong, Peoples R China
[5] Shenzhen Res Inst Populat & Family Planning, Med Genet Lab, Shenzhen, Peoples R China
[6] Guangdong Med Coll, Guangdong Prov Key Lab Med Mol Diag, Dongguan, Peoples R China
[7] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Oncol, Shanghai 200030, Peoples R China
[8] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2013年 / 331卷 / 01期
基金：
中国国家自然科学基金;
关键词：
miRNA; Transcriptional regulation; Transcription machinery; Epigenetic regulation; Cancer; RNA-POLYMERASE-III; NEGATIVE FEEDBACK LOOP; GENE-EXPRESSION; CELL-PROLIFERATION; DOWN-REGULATION; LET-7; MICRORNA; CONSTITUTIVE ACTIVATION; MAMMALIAN MICRORNAS; SKELETAL-MUSCLE; NUCLEAR EXPORT;
D O I：
10.1016/j.canlet.2012.12.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are members of non-coding RNAs. They are involved in diverse biological functions. MiRNAs are precisely regulated in a tissue- and developmental-specific manner, but dysregulated in many human diseases, in particular cancers. Transcriptional regulation, post-transcriptional regulation, as well as genetic alterations, are the three major mechanisms controlling the spatial and temporal expression of miRNAs. Emerging evidence now indicates that transcriptional and epigenetic regulations play major roles in miRNA expression. This review summarizes the current knowledge and discusses the future challenges. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：1 / 10
页数：10
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