Resveratrol: A Focus on Several Neurodegenerative Diseases

被引：135

作者：

Tellone, Ester ^{[1
]}

Galtieri, Antonio ^{[1
]}

Russo, Annamaria ^{[1
]}

Giardina, Bruno ^{[2
,3
]}

Ficarra, Silvana ^{[1
]}

机构：

[1] Univ Messina, Dept Chem Sci, Vle Ferdinando Stagno dAlcontres 31, I-98166 Messina, Italy

[2] Univ Cattolica Sacro Cuore, Sch Med, Biochem & Clin Biochem Inst, I-00168 Rome, Italy

[3] CNR, Inst Chem Mol Recognit, I-00168 Rome, Italy

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2015年 / 2015卷

关键词：

GLYCOGEN-SYNTHASE KINASE-3-BETA; AMYOTROPHIC-LATERAL-SCLEROSIS; FOCAL CEREBRAL-ISCHEMIA; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MITOCHONDRIAL DYSFUNCTION; TRANS-RESVERATROL; RED WINE; HEXANUCLEOTIDE REPEAT; INDUCED NEUROTOXICITY;

D O I：

10.1155/2015/392169

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

引用

页数：14

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