Phenazines and cancer

被引：112

作者：

Cimmino, Alessio ^{[5
]}

Evidente, A. ^{[5
]}

Mathieu, V. ^{[1
,2
]}

Andolfi, A. ^{[5
]}

Lefranc, F. ^{[1
,2
,3
]}

Kornienko, A. ^{[4
]}

Kiss, R. ^{[1
,2
]}

机构：

[1] Fac Pharm, Toxicol Lab, B-1050 Brussels, Belgium

[2] Univ Libre Bruxelles, B-1050 Brussels, Belgium

[3] Univ Libre Bruxelles, Serv Neurochirurg, Hop Erasme, B-1050 Brussels, Belgium

[4] New Mexico Inst Min & Technol, Dept Chem, Socorro, NM 87801 USA

[5] Univ Naples Federico II, Dipartimento Sci Suolo Pianta Ambiente & Prod Ani, I-80055 Portici, Italy

来源：

NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 04期

关键词：

POTENTIAL ANTITUMOR AGENTS; IN-VITRO; STREPTOMYCES-ANTIBIOTICUS; CYTOTOXICITY EVALUATION; SYNTHETIC ANALOGS; TOPOISOMERASE-I; PD 116,152; PHASE-I; XR5944; BIOSYNTHESIS;

D O I：

10.1039/c2np00079b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti-cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti-cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.

引用

页码：487 / 501

页数：15

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