Metabolic signaling functions of ER-mitochondria contact sites: role in metabolic diseases

被引：83
作者：
Tubbs, Emily [1 ]
Rieusset, Jennifer [2 ]
机构：
[1] Lund Univ, Dept Clin Sci, Diabet Ctr, Malmo, Sweden
[2] Charles Merieux Lyon Sud Med Univ, INSERM UMR 1060, CarMeN Lab, INRA U1235,INSA Lyon,Lyon Univ 1, Lyon, France
来源：
JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2017年 / 58卷 / 02期
关键词：
organelle communication; mitochondria-associated membranes; calcium signaling; metabolic homeostasis; insulin resistance; type 2 diabetes mellitus; PP2A; ENDOPLASMIC-RETICULUM STRESS; PROTEIN PHOSPHATASE 2A; INSULIN-RESISTANCE; MOLECULAR-MECHANISMS; REGULATES APOPTOSIS; INTRACELLULAR CA2+; MEMBRANES; DYSFUNCTION; CALCIUM; CELLS;
D O I：
10.1530/JME-16-0189
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER-mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.
引用
收藏
页码：R87 / R106
页数：20
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