DNA methylation signature of interleukin 1 receptor type II in asthma

被引：11
作者：
Gagne-Ouellet, Valerie [1 ]
Guay, Simon-Pierre [2 ,3 ,4 ]
Boucher-Lafleur, Anne-Marie [1 ]
Bouchard, Luigi [2 ,3 ,4 ]
Laprise, Catherine [1 ]
机构：
[1] Univ Quebec Chicoutimi, Dept Sci Fondamentales, Chicoutimi, PQ, Canada
[2] Univ Sherbrooke, Dept Biochem, Sherbrooke, PQ J1K 2R1, Canada
[3] Hop Chicoutimi, ECOGENE 21, Saguenay, PQ, Canada
[4] Hop Chicoutimi, Lipid Clin, Saguenay, PQ, Canada
来源：
CLINICAL EPIGENETICS | 2015年 / 7卷
基金：
加拿大健康研究院;
关键词：
Epigenetics; Methylation; IL1; IL1R1; IL1R2; Asthma; Atopy; HYPOMETHYLATION; GENES; CELLS;
D O I：
10.1186/s13148-015-0114-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-related phenotypes and gene expressions. We found that asthmatic and atopic individuals have higher IL1R2 promoter DNA methylation than control subjects. Additionally, we observed a negative correlation between DNA methylation at the IL1R2 promoter and IL1R2 mRNA expression. These results suggest for the first time that IL1R2 promoter DNA methylation is associated with its gene repression in allergic diseases such as asthma.
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页数：4
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