Total synthesis of a novel non-lactone camptothecin analog through microwave-assisted [3,3]-sigmatropic rearrangement

被引：4
作者：
Kanazawa, Alice [1 ]
Devert, Marie [1 ]
Constant, Jean-Francois [1 ]
Greene, Andrew E. [1 ]
机构：
[1] Univ Grenoble 1, CNRS, Dept Chim Mol, UMR 5250,ICMG FR 2607, F-38041 Grenoble 09, France
来源：
TETRAHEDRON | 2013年 / 69卷 / 14期
关键词：
Total synthesis; Camptothecin analog; Claisen rearrangement; Microwave; Topoisomerase I; RING-MODIFIED CAMPTOTHECIN; TOPOISOMERASE-I; OXIDATION; ALCOHOLS; 22-HYDROXYACUMINATINE; HOMOCAMPTOTHECIN; CLEAVAGE; CPT-11; DRUGS; ACID;
D O I：
10.1016/j.tet.2013.01.091
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, flexible synthesis of a non-lactone camptothecin analog has been accomplished concisely with a microwave-assisted sigmatropic rearrangement as the key step. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3013 / 3018
页数：6
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