Cell type-specific function of TAK1 in innate immune signaling

被引：318

作者：

Ajibade, Adebusola A. ^{[1
]}

Wang, Helen Y. ^{[1
]}

Wang, Rong-Fu ^{[1
]}

机构：

[1] Methodist Hosp, Res Inst, Ctr Inflammat & Epigenet, Houston, TX 77030 USA

来源：

TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 07期

基金：

美国国家卫生研究院;

关键词：

TAK1; complex; NF-kappa B pathway; innate immune signaling; reactive oxygen species; NF-KAPPA-B; ACTIVATED KINASE 1; UBIQUITIN-DEPENDENT KINASE; P38 MAP KINASE; PROTEIN-KINASE; ADAPTER PROTEIN; TARGETING TAK1; TAB1; IL-1; APOPTOSIS;

D O I：

10.1016/j.it.2013.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transforming growth factor beta-activated kinase 1 (TAK1 or MAP3K7) is a key signaling component of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) signaling pathways. Activation of TAK1 is tightly regulated through its binding partners and protein modifications. Although TAK1 functions as an essential and positive regulator of innate immune signaling and apoptosis in mouse embryonic fibroblasts (MEFs), T cells, and other cells, it negatively regulates cell development and activation of proinflammatory signaling pathways in neutrophils. However, the molecular mechanisms responsible for the opposite roles of TAK1 in different cell types remain to be addressed. In this article, we discuss the latest progresses in our understanding of TAK1 regulation, function, and mechanisms in a cell-type specific manner.

引用

页码：307 / 316

页数：10

共 107 条

[1] Ubiquitin-mediated activation of TAK1 and IKK [J].

Adhikari, A. ;

Xu, M. ;

Chen, Z. J. .

ONCOGENE, 2007, 26 (22) :3214-3226

[2] The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation [J].

Ahmed, Neesar ;

Zeng, Minghui ;

Sinha, Indrajit ;

Polin, Lisa ;

Wei, Wei-Zen ;

Rathinam, Chozhavendan ;

Flavell, Richard ;

Massoumi, Ramin ;

Venuprasad, K. .

NATURE IMMUNOLOGY, 2011, 12 (12) :1176-U1

[3]

Ajibade AA, 2012, IMMUNITY, V36, P43, DOI 10.1016/j.immuni.2011.12.010

[4] Neutrophil Function: From Mechanisms to Disease [J].

Amulic, Borko ;

Cazalet, Christel ;

Hayes, Garret L. ;

Metzler, Kathleen D. ;

Zychlinsky, Arturo .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :459-489

[5] Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-κB [J].

Asehnoune, K ;

Strassheim, D ;

Mitra, S ;

Kim, JY ;

Abraham, E .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2522-2529

[6] Modulation of life and death by the TNF receptor superfamily [J].

Baker, SJ ;

Reddy, EP .

ONCOGENE, 1998, 17 (25) :3261-3270

[7] An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[8] TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer [J].

Bettermann, Kira ;

Vucur, Mihael ;

Haybaeck, Johannes ;

Koppe, Christiane ;

Janssen, Joern ;

Heymann, Felix ;

Weber, Achim ;

Weiskirchen, Ralf ;

Liedtke, Christian ;

Gassler, Nikolaus ;

Mueller, Michael ;

de Vos, Rita ;

Wolf, Monika Julia ;

Boege, Yannick ;

Seleznik, Gitta Maria ;

Zeller, Nicolas ;

Erny, Daniel ;

Fuchs, Thomas ;

Zoller, Stefan ;

Cairo, Stefano ;

Buendia, Marie-Annick ;

Prinz, Marco ;

Akira, Shizuo ;

Tacke, Frank ;

Heikenwalder, Mathias ;

Trautwein, Christian ;

Luedde, Tom .

CANCER CELL, 2010, 17 (05) :481-496

[9] Essential role of TAK1 in regulating mantle cell lymphoma survival [J].

Buglio, Daniela ;

Palakurthi, Sangeetha ;

Byth, Kate ;

Vega, Francisco ;

Toader, Dorin ;

Saeh, Jamal ;

Neelapu, Sattva S. ;

Younes, Anas .

BLOOD, 2012, 120 (02) :347-355

[10] Ubiquitin, TAK1 and IKK: is there a connection? [J].

Chen, ZJ ;

Bhoj, V ;

Seth, RB .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (05) :687-692

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