Cognitive Effects of Subthalamic Nucleus Stimulation in Parkinson's Disease: A Controlled Study

被引：35
作者：
Saez-Zea, Carmen [3 ]
Escamilla-Sevilla, Francisco
Katati, Majed J. [2 ]
Minguez-Castellanos, Adolfo [1 ]
机构：
[1] Hosp Univ Virgen de las Nieves, Serv Neurol, Dept Neurol, Movement Disorders Unit, ES-18013 Granada, Spain
[2] Hosp Univ Virgen de las Nieves, Dept Neurosurg, Movement Disorders Unit, ES-18013 Granada, Spain
[3] Univ Jaen, Dept Psychol, Area Psychobiol, Fac Humanities & Educ, Jaen, Spain
来源：
EUROPEAN NEUROLOGY | 2012年 / 68卷 / 06期
关键词：
Cognition; Deep brain stimulation; Neuropsychological testing; Parkinson's disease; Subthalamic nucleus; Verbal fluency; DEEP-BRAIN-STIMULATION; RANDOMIZED CONTROLLED-TRIAL; STN-DBS; MEDICAL THERAPY; PD; PET;
D O I：
10.1159/000341380
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor function in selected patients with Parkinson's disease (PD) but can be associated with variable changes in cognitive functions. Methods: We studied 21 patients selected for STN-DBS and compared 6-month clinical and neuropsychological outcomes between those who underwent surgery (n = 9) and those who voluntarily refused it (n = 12). Results: Motor and quality of life outcomes were markedly superior in the STN-DBS group versus controls. A wide neuropsychological battery was administered, and the whole sample showed a statistically significant worsening in phonemic verbal fluency, time to perform the Trail Making Test part B, Digit Symbol score of WAIS-III and color-naming score of the Stroop Test. In comparison to controls, a trend to a slightly worse deterioration in phonemic verbal fluency was observed in the STN-DBS patients and was significantly correlated with reductions in the L-dopa-equivalent daily dose (r = 0.850, p = 0.007). Conclusion: Our study confirms the safety of STN-DBS from a cognitive standpoint; a reduction in verbal fluency at 6 months after surgery can also be related to PD progression and medication reduction. Copyright (C) 2012 S. Karger AG, Basel
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页码：361 / 366
页数：6
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