Polyoxygenated cembranoids from the South China Sea soft coral Sarcophyton boettgeri and their stereochemistry

被引：2

作者：

Liu, Jiao ^{[1
,2
]}

Xu, Ting ^{[2
]}

Yao, Li-Gong

Li, Song-Wei ^{[3
]}

Guo, Yue-Wei ^{[1
,2
,4
,5
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China

[2] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China

[3] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

[4] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China

[5] Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China

来源：

FITOTERAPIA | 2022年 / 162卷

关键词：

Soft coral; Sarcophyton boettgeri; Cembranoid; Absolute configuration; DITERPENOIDS; TROCHELIOPHORUM; STEROIDS;

D O I：

10.1016/j.fitote.2022.105299

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new polyoxygenated cembranoids, namely sarcoboettgerol A (1), 12-epi-humilisin D (2), sarcoboettgerol B (3), and sarcoboettgerol C (4), together with one known related analogue, humilisin D (5), were isolated and characterized from the soft coral Sarcophyton boettgeri collected off Ximao island, Hainan Province, China. The structures and absolute configurations of the new compounds were determined by extensive spectroscopic data analyses, Cu k alpha single crystal X-ray diffraction analysis, and TDDFT-ECD calculations. A plausible biogenetic relationship of 3 and 4 was proposed.

引用

页数：7

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