Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: A literature review

被引:139
作者
Su, Jiann-Sheng [1 ]
Chen, Yu-Tso [2 ]
Wang, Ren-Ching [3 ]
Wu, Chun-Ying [2 ,4 ]
Lee, Shou-Wu [2 ,5 ]
Lee, Teng-Yu [2 ,4 ,5 ]
机构
[1] Kuang Tien Gen Hosp, Div Gastroenterol & Hepatol, Taichung 433, Taiwan
[2] Taichung Vet Gen Hosp, Div Gastroenterol & Hepatol, Taichung 407, Taiwan
[3] Taichung Vet Gen Hosp, Dept Pathol & Lab Med, Taichung 407, Taiwan
[4] China Med Univ, Grad Inst Clin Med Sci, Taichung 404, Taiwan
[5] Chung Shan Med Univ, Dept Med, Taichung 402, Taiwan
关键词
Hepatocellular carcinoma; Alpha-fetoprotein-producing tumor; Alpha fetoprotein; Gastric adenocarcinoma; Pathology; OF-THE-LITERATURE; HEPATOCELLULAR-CARCINOMA; GASTRIC-CARCINOMA; ALPHA-FETOPROTEIN; IMMUNOHISTOCHEMICAL ANALYSIS; ONCOFETAL PROTEIN; HEP PAR-1; EXPRESSION; STOMACH; CANCER;
D O I
10.3748/wjg.v19.i3.321
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatoid adenocarcinoma (HAC) is a rare but important special type of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma (HCC), and prompt and correct diagnosis can be a challenge, especially in endemic areas with a high incidence of HCC. To date, HAC has only been reported in case series or single case reports, so we aimed to review the clinicopathological characteristics of HAC to obtain a more complete picture of this rare form of extrahepatic adenocarcinoma. All the articles about HAC published from 2001 to 2011 were reviewed, and clinicopathological findings were extracted for analysis. A late middle-aged male with high serum alpha-fetoprotein and atypical image finding of HCC should raise the suspicion of HAC, and characteristic pathological immunohistochemical stains can help with the differential diagnosis. Novel immunohistochemical markers may be useful to clearly differentiate HAC from HCC. Once metastatic HAC is diagnosed, the primary tumor origin should be identified for adequate treatment. The majority of HAC originates from the stomach, so panendoscopy should be arranged first. (C) 2013 Baishideng. All rights reserved.
引用
收藏
页码:321 / 327
页数:7
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