A highly sensitive fluorescent probe based on simple pyrazoline for Zn2+ in living neuron cells

被引：53

作者：

Zhang, Zhe ^{[1
]}

Wang, Fang-Wu ^{[2
]}

Wang, Sheng-Qing ^{[1
]}

Ge, Fei ^{[1
]}

Zhao, Bao-Xiang ^{[1
]}

Miao, Jun-Ying ^{[2
]}

机构：

[1] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 43期

基金：

中国国家自然科学基金;

关键词：

MITOCHONDRIAL ZINC IONS; AQUEOUS-SOLUTION; CHARGE-TRANSFER; SENSOR; CHEMOSENSOR; CYTOTOXICITY; HOMEOSTASIS; MOLECULE; RELEASE;

D O I：

10.1039/c2ob26375k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We develop a pyrazoline-based fluorescent sensor for biological Zn2+ detection. The sensor shows good binding selectivity for Zn2+ over competing metal with 40-fold fluorescence enhancement in response to Zn2+. The new probe is cell-permeable and can be used to detect intracellular zinc ions in living neuron cells.

引用

页码：8640 / 8644

页数：5

共 42 条

[41] A Novel Sensitive Turn-on Fluorescent Zn2+ Chemosensor Based on an Easy To Prepare C3-Symmetric Schiff-Base Derivative in 100% Aqueous Solution [J].

Zhou, Ying ;

Li, Zhan-Xian ;

Zang, Shuang-Quan ;

Zhu, Yan-Yan ;

Zhang, Hong-Yan ;

Hou, Hong-Wei ;

Mak, Thomas C. W. .

ORGANIC LETTERS, 2012, 14 (05) :1214-1217

[42] A selective 'Off-On' fluorescent sensor for Zn2+ based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn2+ [J].

Zhou, Ying ;

Kim, Ha Na ;

Yoon, Juyoung .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (01) :125-128

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