Nanoparticle-based immunoassays in the biomedical field

被引：91

作者：

Tang, Dianping ^{[1
]}

Cui, Yuling ^{[1
]}

Chen, Guonan ^{[1
]}

机构：

[1] Fuzhou Univ, Minist Educ, Dept Chem, Key Lab Anal & Detect Food Safety,Fujian Prov Key, Fuzhou 350108, Peoples R China

来源：

ANALYST | 2013年 / 138卷 / 04期

基金：

美国国家科学基金会; 高等学校博士学科点专项科研基金;

关键词：

SENSITIVE ELECTROCHEMICAL IMMUNOASSAY; LATERAL-FLOW IMMUNOASSAY; SURFACE-PLASMON RESONANCE; ELECTROCHEMILUMINESCENCE IMMUNOSENSOR; ULTRASENSITIVE DETECTION; GOLD NANOPARTICLES; CANCER BIOMARKER; MAGNETIC BEADS; ELECTROGENERATED CHEMILUMINESCENCE; IMMUNOCHROMATOGRAPHIC ASSAY;

D O I：

10.1039/c2an36500f

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Recent research has looked to develop innovative, powerful and novel biofunctionalized nanoparticles, controlling and tailoring their properties in a very predictable manner to meet the needs of clinic immunoassays in the biomedical field. This minireview briefly summarizes recent advances covering the last 3 years, exploiting nanoparticle-based electrochemical, optical, mass-sensitive, colorimetric and immunodipstick assays. The enormous signal enhancement associated with the use of nanoparticles and formation of nanoparticle-antibody-antigen assemblies provide the basis for sensitive detection of disease-related proteins or biomarkers. Rather than being exhaustive, this minireview focuses on selected examples to illustrate novel concepts and promising applications. Finally, a small amount of speculation of possible future developments in nanoparticle-based immunoassays is provided.

引用

页码：981 / 990

页数：10

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