Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents

被引:59
作者
Chakraborty, Amlan [1 ,3 ]
Boer, Jennifer C. [3 ]
Selomulya, Cordelia [1 ]
Plebanski, Magdalena [2 ,3 ]
机构
[1] Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia
[2] Monash Univ, Monash Inst Med Engn, Clayton, Vic 3800, Australia
[3] Monash Univ, Cent Clin Sch, Dept Immunol & Pathol, Melbourne, Vic 3004, Australia
基金
澳大利亚研究理事会;
关键词
IRON-OXIDE NANOPARTICLES; ALLERGIC AIRWAY INFLAMMATION; ON FLUORESCENT BIOSENSOR; WALLED CARBON NANOTUBES; GOLD NANOPARTICLES; CELLULAR UPTAKE; SILVER NANOPARTICLES; MAGNETIC NANOPARTICLES; ANTIBACTERIAL ACTIVITY; FUTURE-PROSPECTS;
D O I
10.1021/acs.bioconjchem.7b00455
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The field of medical diagnostics and therapeutics is being revolutionized by nanotechnology, from targeted drug delivery to cancer immunotherapy. Inorganic nano particles are widely used, albeit problems with agglutination, cytotoxicity, free radical generation, and instability in some biological environments limits their utility. Conjugation of biomolecules such as peptides to the surface of nanoparticles can mitigate such problems, as well as confer specialized theranostic (therapeutic and/or diagnostic) properties, useful across biomedical applications such as vaccines, drug delivery, and in vivo imaging. Coating with amino acids, rather than peptides, offers further a highly cost-effective approach (due to their ease of purification and availability), but is currently an underutilized way to decrease toxicity and enhance stability. Amino acid molecules are small (< 200 Da) and have both positive and negative charge groups (zwitterionic) facilitating charge-specific molecule binding. Additionally, amino acids exert by themselves some useful biological functions, with antibacterial and viability enhancing properties (for eukaryotic cells). Overall particle size, nanoparticle core, and the specific amino acid used to functionalize their surface influence their biodistribution, and their effects on host immunity. In this review, we provide for the first time an overview of this emerging field, and identify gaps in knowledge for future research.
引用
收藏
页码:657 / 671
页数:15
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