Rab3A small GTP-binding protein in Ca2+-dependent exocytosis

被引：101
作者：
Takai, Y
Sasaki, T
Shirataki, H
Nakanishi, H
机构：
[1] OSAKA UNIV,SCH MED,DEPT MOL BIOL & BIOCHEM,SUITA,OSAKA 565,JAPAN
[2] RES DEV CORP JAPAN,ERATO,TAKAI BIOTIMER PROJECT,KOBE 65122,JAPAN
来源：
GENES TO CELLS | 1996年 / 1卷 / 07期
关键词：
D O I：
10.1046/j.1365-2443.1996.00257.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
There exists a small GTP-binding protein (G protein) superfamily, consisting of more than 50 members, from yeast to mammal. The Rab family belongs to this superfamily and is implicated in intracellular vesicle trafficking. Rab3A small G protein is a member of the Rab3 subfamily which belongs to this Rab family. The regulators and downstream targets of Rab3A have been isolated, and evidence is accumulating that Rab3A and these Rab3A-interacting proteins are involved in Ca2+-dependent exocytosis, particularly in neurotransmitter release from nerve terminals.
引用
收藏
页码：615 / 632
页数：18
相关论文
共 108 条
[41]  
KIKUCHI A, 1988, J BIOL CHEM, V263, P2897
[42]  
KISHIDA S, 1993, J BIOL CHEM, V268, P22259
[43]   Involvement of rabphilin-3A in Ca2+-dependent exocytosis from PC12 cells [J].
Komuro, R ;
Sasaki, T ;
Orita, S ;
Maeda, M ;
Takai, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (02) :435-440
[44]   RAB3-PEPTIDE STIMULATES EXOCYTOSIS FROM MAST-CELLS VIA A PERTUSSIS-TOXIN-SENSITIVE MECHANISM [J].
LAW, GJ ;
NORTHROP, AJ ;
MASON, WT .
FEBS LETTERS, 1993, 333 (1-2) :56-60
[45]   SYNAPTIC TARGETING OF RABPHILIN-3A, A SYNAPTIC VESICLE CA2+/PHOSPHOLIPID-BINDING PROTEIN, DEPENDS ON RAB3A/3C [J].
LI, C ;
TAKEI, K ;
GEPPERT, M ;
DANIELL, L ;
STENIUS, K ;
CHAPMAN, ER ;
JAHN, R ;
DECAMILLI, P ;
SUDHOF, TC .
NEURON, 1994, 13 (04) :885-898
[46]   CA2+-DEPENDENT AND CA2+-INDEPENDENT ACTIVITIES OF NEURAL AND NONNEURAL SYNAPTOTAGMINS [J].
LI, C ;
ULLRICH, B ;
ZHANG, JZ ;
ANDERSON, RGW ;
BROSE, N ;
SUDHOF, TC .
NATURE, 1995, 375 (6532) :594-599
[47]   STIMULATION OF INSULIN RELEASE FROM PERMEABILIZED HIT-T15 CELLS BY A SYNTHETIC PEPTIDE CORRESPONDING TO THE EFFECTOR DOMAIN OF THE SMALL GTP-BINDING PROTEIN RAB3 [J].
LI, GD ;
REGAZZI, R ;
BALCH, WE ;
WOLLHEIM, CB .
FEBS LETTERS, 1993, 327 (02) :145-149
[48]   YPT1P IMPLICATED IN V-SNARE ACTIVATION [J].
LIAN, JP ;
STONE, S ;
JIANG, Y ;
LYONS, P ;
FERRONOVICK, S .
NATURE, 1994, 372 (6507) :698-701
[49]   INHIBITION OF RAB3B EXPRESSION ATTENUATES CA2+-DEPENDENT EXOCYTOSIS IN RAT ANTERIOR-PITUITARY-CELLS [J].
LLEDO, PM ;
VERNIER, P ;
VINCENT, JD ;
MASON, WT ;
ZOREC, R .
NATURE, 1993, 364 (6437) :540-544
[50]   MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL TYPE OF REGULATORY PROTEIN (GDI) FOR SMG P25A, A RAS P21-LIKE GTP-BINDING PROTEIN [J].
MATSUI, Y ;
KIKUCHI, A ;
ARAKI, S ;
HATA, Y ;
KONDO, J ;
TERANISHI, Y ;
TAKAI, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) :4116-4122
12345678910