4-Phosphatephenyl Covalently Modified Glassy Carbon Electrode for Real-Time Electrochemical Monitoring of Paracetamol Release from Electrospun Nanofibers

被引：11

作者：

Yang, Guocheng ^{[1
]}

Wang, Lu ^{[1
]}

Yang, Yingshu ^{[1
]}

Chen, Xuesong ^{[3
]}

Zhou, Defeng ^{[1
]}

Jia, Jianbo ^{[2
]}

Li, Dongfeng ^{[1
]}

机构：

[1] Changchun Univ Technol, Sch Chem & Life Sci, Changchun 130012, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 3, Dept Med Oncol, Harbin 150040, Peoples R China

来源：

ELECTROANALYSIS | 2012年 / 24卷 / 10期

基金：

中国国家自然科学基金;

关键词：

4-Phosphatephenyl; Modified electrode; Paracetamol; Electrospinning; Drug release; DRUG-DELIVERY SYSTEM; PERFORMANCE LIQUID-CHROMATOGRAPHY; IN-VIVO EVALUATION; AQUEOUS-SOLUTIONS; VITRO; REDUCTION; COMPOSITE; SURFACE; DESIGN;

D O I：

10.1002/elan.201200230

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A glassy carbon electrode (GCE) was covalently modified by 4-phosphatephenyl (4-PP). Sensing paracetamol (PCT) via linear sweep voltammetry in sulfuric buffer solution of pH 1.02 at 36.8?degrees C, the 4-PP-modified GCE showed high electrochemical sensitivity and long reusability. PCT-loaded poly(vinyl alcohol) (PVA) nanofibers were prepared by electrospinning. Based on the calibration curve of PCT on the 4-PP-modified GCE, the PCT release process from the nanofibers was electrochemically monitored in real time via two routes. The results showed that the covalently modified GCE can be repeatedly used as real-time electrochemical monitoring platform for drug release from drug-loaded nanofibers in the long term.

引用

页码：1937 / 1944

页数：8

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