The βc receptor family - Structural insights and their functional implications

被引：56
作者：
Broughton, Sophie E. [1 ]
Nero, Tracy L. [1 ]
Dhagat, Urmi [1 ]
Kan, Winnie L. [2 ,3 ]
Hercus, Timothy R. [2 ,3 ]
Tvorogov, Denis [2 ,3 ]
Lopez, Angel F. [2 ,3 ]
Parker, Michael W. [1 ,4 ]
机构：
[1] St Vincents Inst Med Res, Australian Canc Res Fdn Rat Drug Discovery Ctr, Fitzroy, Vic 3065, Australia
[2] SA Pathol, Ctr Canc Biol, Adelaide, SA 5000, Australia
[3] Univ S Australia, Adelaide, SA 5000, Australia
[4] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia
来源：
CYTOKINE | 2015年 / 74卷 / 02期
基金：
英国医学研究理事会;
关键词：
Granulocyte-macrophage colony stimulating factor; Interleukin-3; Interleukin-5; Beta common receptor; Inflammation; COLONY-STIMULATING FACTOR; GM-CSF RECEPTOR; GROWTH-HORMONE RECEPTOR; HIGH-AFFINITY BINDING; ACUTE MYELOGENOUS LEUKEMIA; ALPHA-CHAIN; HUMAN INTERLEUKIN-5; CYTOKINE RECEPTORS; IL-5; RECEPTORS; CRYSTAL-STRUCTURE;
D O I：
10.1016/j.cyto.2015.02.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (beta c). These cytokines regulate the growth, differentiation, migration and effector function activities of many hematopoietic cells in bone marrow, blood and sites of inflammation. Excessive or aberrant signaling can result in chronic inflammatory conditions and myeloid leukemias. The crystal structures of the GM-CSF ternary complex, the IL-5 binary complex and the very recent IL-3 receptor alpha subunit build upon decades of structure-function studies, giving new insights into cytokine-receptor specificity and signal transduction. Selective modulation of receptor function is now a real possibility and the structures of the beta c receptor family are being used to discover novel and disease-specific therapeutics. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：247 / 258
页数：12
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