Pathogenetic investigations into the Wasting Marmoset Syndrome in common marmosets (Callithrix jacchus)

The Wasting Marmoset Syndrome (WMS) is a disease that affects captive callitrichids and causes substantial problems in zoological and experimental marmoset husbandry So far pathogenetic mechanisms and etiologic factors of this complex syndrome could not be identified. The WMS is characterized by progressive weight loss despite of normal food intake and a deteriorating general condition. Chronic diarrhea, alopecia, muscle atrophy, chronic colitis as well as alterations of liver and kidneys are regarded as associated features of the disease. Recent studies about the WMS indicate that inflammatory intestinal changes play a decisive role in the pathogenesis of the disease.