Protective actions of the 5-HT2A/2C, receptor agonist, DOI, on 5-HT1A receptor-mediated inhibition of lordosis behavior

被引：29
作者：
Maswood, S [1 ]
Andrade, M [1 ]
CaldarolaPastuszka, M [1 ]
Uphouse, L [1 ]
机构：
[1] TEXAS WOMANS UNIV,DEPT BIOL,DENTON,TX 76204
来源：
NEUROPHARMACOLOGY | 1996年 / 35卷 / 04期
关键词：
5-HT (serotonin); 5-HT1A receptor; 5-HT2A/2C receptors; proestrous rats; sexual behavior; ventromedial nucleus (hypothalamus);
D O I：
10.1016/0028-3908(95)00195-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sexually receptive proestrous rats were infused bilaterally into the ventromedial nucleus of the hypothalamus (VMN) with 200 ng of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), 1000 or 2000 ng of 5-methoxy-3-(di-n-propylamino) chroman (5-MEO-DPAC), or 1000 or 2000 ng of serotonin (5-HT) plus or minus the 5-HT2A/2C agonist, (2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI). DOI protected against the lordosis-inhibiting effects of 5-HT and each of the 5-HT1A agonists. These results substantiate a prior report that 2000 ng DOI could protect against the lordosis-inhibiting action of 200 ng 8-OH-DPAT and demonstrate that such protection is not unique to a single 5-HT1A agonist. Consequently, these results strengthen evidence that functionally significant interactions occur among 5-HT receptors within the VMN. (C) 1996 Elsevier Science Ltd.
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收藏
页码：497 / 501
页数：5
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