Autophagy and Immune-Related Diseases

被引：2

作者：

Jin, Min ^{[1
]}

Zhang, Yanyun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai, Peoples R China

来源：

AUTOPHAGY: BIOLOGY AND DISEASES: CLINICAL SCIENCE | 2020年 / 1207卷

关键词：

Autophagy; Atherosclerosis; Graft-versus-host disease; Inflammatory liver disease;

D O I：

10.1007/978-981-15-4272-5_27

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As a result of its multifunction both in innate and adaptive immune systems, autophagy has been demonstrated to take part in the pathogenesis of several immune-related diseases. The study on the pathological mechanism of autophagy in these diseases may provide an experimental and theoretical basis for targeted intervention of autophagy in the prevention and treatment of immune diseases. To date, it has been reported that autophagy can eliminate impaired mitochondrial to inhibit the activation ofNLRP3 inflammasome which promotes the progression of atherosclerosis. Moreover, enhanced autophagy can effectively prevent the occurrence of GVHD. It also plays a key role in the development of viral hepatitis. Therefore, autophagy might be a promising regulatory target for the treatment of immune-related diseases.

引用

页码：401 / 403

页数：3

共 5 条

[1] Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice [J].

Han, Jihye ;

Bae, Joonbeom ;

Choi, Chang-Yong ;

Choi, Sang-Pil ;

Kang, Hyung-Sik ;

Jo, Eun-Kyeong ;

Park, Jongsun ;

Lee, Young Sik ;

Moon, Hyun-Seuk ;

Park, Chung-Gyu ;

Lee, Myung-Shik ;

Chun, Taehoon .

AUTOPHAGY, 2016, 12 (12) :2326-2343

[2] Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells [J].

Hubbard-Lucey, Vanessa M. ;

Shono, Yusuke ;

Maurer, Katie ;

West, Mallory L. ;

Singer, Natalie V. ;

Ziegler, Carly G. K. ;

Lezcano, Cecilia ;

Motta, Ana Carolina Fragoso ;

Schmid, Karin ;

Levi, Samuel M. ;

Murphy, George F. ;

Liu, Chen ;

Winkler, Jeffrey D. ;

Amaravadi, Ravi K. ;

Rogler, Gerhard ;

Dickinson, Anne M. ;

Holler, Ernst ;

van den Brink, Marcel R. M. ;

Cadwell, Ken .

IMMUNITY, 2014, 41 (04) :579-591

[3] Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection [J].

Rautou, Pierre-Emmanuel ;

Cazals-Hatem, Dominique ;

Feldmann, Gerard ;

Mansouri, Abdellah ;

Grodet, Alain ;

Barge, Sandrine ;

Martinot-Peignoux, Michele ;

Duces, Aurelie ;

Bieche, Ivan ;

Lebrec, Didier ;

Bedossa, Pierre ;

Paradis, Valerie ;

Marcellin, Patrick ;

Valla, Dominique ;

Asselah, Tarik ;

Moreau, Richard .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (06) :2708-2715

[4] Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles [J].

Tanida, Isei ;

Fukasawa, Masayoshi ;

Ueno, Takashi ;

Kominami, Eiki ;

Wakita, Takaji ;

Hanada, Kentaro .

AUTOPHAGY, 2009, 5 (07) :937-945

[5] A role for mitochondria in NLRP3 inflammasome activation [J].

Zhou, Rongbin ;

Yazdi, Amir S. ;

Menu, Philippe ;

Tschopp, Juerg .

NATURE, 2011, 469 (7329) :221-225

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