A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance

被引：185

作者：

Xiao, Haihua ^{[1
,2
]}

Song, Haiqin ^{[3
]}

Yang, Qiang ^{[4
]}

Cai, Haidong ^{[5
]}

Qi, Ruogu ^{[1
,2
]}

Yan, Lesan ^{[1
,2
]}

Liu, Shi ^{[1
]}

Zheng, Yonghui ^{[1
]}

Huang, Yubin ^{[1
]}

Liu, Tongjun ^{[3
]}

Jing, Xiabin ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Jilin Univ, China Japan Union Hosp, Dept Colorectal & Anal Surg, Changchun 130033, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Obstet & Gynecol, Wuhan 430074, Peoples R China

[5] Changchun Univ Sci & Technol, Dept Chem & Environm Engn, Changchun 130022, Peoples R China

来源：

BIOMATERIALS | 2012年 / 33卷 / 27期

基金：

中国国家自然科学基金;

关键词：

Platinum drug; Paclitaxel; Combination therapy; Drug delivery; Micelles; COMBINATION CHEMOTHERAPY; BIODEGRADABLE POLYMER; DRUG; THERAPY; CANCER; REDUCTION; RECURRENT; TAXOL; ACID;

D O I：

10.1016/j.biomaterials.2012.05.049

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A strategy of preparing composite micelles containing both cisplatin(IV) prodrug and paclitaxel was developed, i.e., synthesizing a cisplatin(IV) conjugate and a paclitaxel conjugate starting with the same biodegradable and amphiphilic block copolymer, and co-assembling the two conjugates. The composite micelles could release effective anticancer drug cisplatin(II) upon cellular reduction and PTX via acid hydrolysis once they came into the cancerous cells. Moreover, the composite micelles displayed synergistic effect in vitro and the combination therapy in micellar dosage-form led to reduced systematic toxicity and enhanced antitumor efficacy in vivo. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6507 / 6519

页数：13

共 31 条

[1] Intraperitoneal cisplatin and paclitaxel in ovarian cancer [J].