Towards Ideal Synthesis: Alkenylation of Aryl C-H Bonds by a Fujiwara-Moritani Reaction

被引：206

作者：

Zhou, Lihong ^{[1
]}

Lu, Wenjun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Chem, Shanghai 200240, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

arenes; C-C bond formation; C-H activation; Fujiwara-Moritani reaction; oxidative coupling; OXIDATIVE COUPLING REACTION; OXIDIZING DIRECTING GROUP; PD(II)-CATALYZED OLEFINATION; AROMATIC SUBSTITUTION; PHENOL DERIVATIVES; ROOM-TEMPERATURE; OPEN ATMOSPHERE; ACTIVATION; ARENES; ALKENES;

D O I：

10.1002/chem.201303670

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An overview of recent progress in the Fujiwara-Moritani reaction, which is the palladium-catalyzed oxidative coupling of arenes with olefins to afford alkenyl arenes, is described. It is emphasized that regioselectivity on aryl ortho- or meta-C-H activation could be controlled very well in the presence of Pd, Rh, or Ru catalysts with the assistance of various chelation groups on aromatic rings in this coupling reaction. Catalytic alkenylation of aryl C-H bonds from simple arenes is also discussed, especially from electron-deficient arenes. These advanced protocols would not only make the Fujiwara-Moritani reaction more useful and applicable in organic synthesis but also light the way for the further development of the functionalization of normal C-H bonds.

引用

页码：634 / 642

页数：9

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