A novel colorimetric assay for rapid detection of cysteine and Hg2+ based on gold clusters

被引：66

作者：

Wang, Yi-Wei ^{[1
]}

Tang, Shurong ^{[2
]}

Yang, Huang-Hao ^{[3
]}

Song, Hongbo ^{[1
]}

机构：

[1] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China

[2] Fujian Med Univ, Dept Pharmaceut Anal, Fac Pharm, Fuzhou 350004, Fujian, Peoples R China

[3] Fuzhou Univ, Dept Chem, Key Lab Anal & Detect Food Safety MOE, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Fuzhou 350108, Peoples R China

来源：

TALANTA | 2016年 / 146卷

基金：

中国国家自然科学基金;

关键词：

Colorimetric sensor; Cysteine; Hg2+; Gold clusters; Rapid detection; FLUORESCENT-PROBE; COMPETITION ASSAY; NANOPARTICLES; MERCURY(II); NANOCLUSTERS; AGGREGATION; RANGE;

D O I：

10.1016/j.talanta.2015.08.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Inhibition and recovery of the catalytic activity of bovine serum albumin-capped gold nanoclusters (BSA-AuNCs) is observed for the first time by introduction of cysteine and Hg2+. The prepared BSA-AuNCs possess highly intrinsic peroxidase-like activity. It can catalyze the oxidation of 3, 3, 5, 5-tetramethylbenzidine by H2O2 to produce a blue colored product. Based on this phenomenon, a new colorimetric assay for rapid, selective and sensitive detection of cysteine and Hg2+ in aqueous solution has been demonstrated. The interaction process between target molecule and BSA-AuNCs is very fast, so that the whole test can be completed within ten minutes. Moreover, the fabricated calorimetric sensor is simple and cost-effective, without the need of nucleic acid based recognition element and complicated washing, separation and labeling process, thus holds great promise for routine analysis of cysteine and Hg2+ in real samples. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：71 / 74

页数：4

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