CD38 as immunomodulator in cancer

被引：23

作者：

Li, Yanli ^{[1
]}

Yang, Rui ^{[1
]}

Chen, Limo ^{[2
]}

Wu, Sufang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Shanghai, Peoples R China

[2] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

来源：

FUTURE ONCOLOGY | 2020年 / 16卷 / 34期

关键词：

biomarker; cancer immunotherapy; CD38; immune checkpoint therapy; immunomodulation; tumor microenvironment; ANTIBODIES TARGETING CD38; MONOCLONAL-ANTIBODIES; BONE-MARROW; ADP-RIBOSE; ANTI-CD38; AUTOANTIBODIES; MULTIPLE-MYELOMA; DENDRITIC CELLS; LUNG-CANCER; EXPRESSION; DARATUMUMAB;

D O I：

10.2217/fon-2020-0401

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 protein was previously considered as a cell activation marker, and today monoclonal antibodies targeting CD38 have witnessed great achievements in multiple myeloma and promoted researchers to conduct research on other tumors. In this review, we provide a wide-ranging review of the biology and function of the human molecule outside the field of myeloma. We focus mainly on current research findings to summarize and update the findings gathered from diverse areas of study. Based on these findings, we attempt to extend the role of CD38 in the context of therapy of solid tumors and expand the role of the molecule from a simple marker to an immunomodulator.

引用

页码：2853 / 2861

页数：9

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