Synthesis of Azaheterocyclic Vinylphosphonates by Ring-Closing Metathesis

被引：12

作者：

Garzon, Cecile ^{[1
]}

Attolini, Mireille ^{[1
]}

Maffei, Michel ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, ISm2, UMR 7313, F-13397 Marseille, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 18期

关键词：

Nitrogen heterocycles; Organocatalysis; Metathesis; Phosphorus; Ruthenium; OLEFIN METATHESIS; MANNICH REACTION; BETA-AMINO; ACID; INHIBITORS; PHOSPHORUS; ROUTE; ISOMERIZATION; HETEROCYCLES; DERIVATIVES;

D O I：

10.1002/ejoc.201300375

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds were synthesized by ruthenium-catalyzed ring-closing metathesis of N-tosyl-N-(-alkenyl)aminomethylvinyl phosphonates, which were obtained from N-(-alkenyl)-N-tosylamides. These compounds, in turn, were prepared from unsaturated alcohols through the Mitsunobu reaction. This methodology gives access to five- and six-membered ring compounds. Additionally, chiral phosphonates can be obtained easily.

引用

页码：3653 / 3657

页数：5

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