Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease

被引：65

作者：

Funk, Natalja ^{[1
,2
]}

Wieghofer, Peter ^{[1
,2
]}

Grimm, Sabrina ^{[3
]}

Schaefer, Richard ^{[4
,5
]}

Buehring, Hans-Joerg ^{[3
]}

Gasser, Thomas ^{[1
,2
]}

Biskup, Saskia ^{[1
,2
]}

机构：

[1] Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[2] German Ctr Neurodegenerat Dis, D-72076 Tubingen, Germany

[3] Univ Clin Tuebingen, Lab Stem Cell Res, Dept Internal Med 2, Div Hematol Oncol Immunol Rheumatol & Pneumonol, Tubingen, Germany

[4] Univ Clin Tuebingen, Inst Clin & Expt Transfus Med, Tubingen, Germany

[5] Stanford Univ, Sch Med, Stanford Inst Neuroinnovat & Translat Neurosci, Stanford, CA 94305 USA

来源：

MOVEMENT DISORDERS | 2013年 / 28卷 / 03期

关键词：

neurodegeneration; Parkinson's disease; neuroinflammation; innate immunity; BLOOD-BRAIN-BARRIER; SUBSTANTIA-NIGRA; TNF-ALPHA; ALZHEIMERS; MICROGLIA; INTERLEUKIN-1-BETA; CCR2; MICE;

D O I：

10.1002/mds.25300

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Emerging evidence has highlighted the pivotal role of the immune system in neurodegenerative diseases. This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the peripheral blood of Parkinson's patients. Methods: A colony-forming cell assay was established to study hematopoietic stem cells from venous blood of Parkinson's patients, and flow cytometry was used to analyze the expression of chemokine receptors on monocytes. Results We demonstrate that there is strong upregulation in the percentage of monocyte precursors in the peripheral blood of Parkinson's patients and asymptomatic high-risk individuals. We identify the receptor CCR2 as undergoing strong upregulation on the surface of classical monocytes in Parkinson's patients. Conclusions The association between blood cell development and progressive cell death in the brain of Parkinson's patients should be further investigated as a potential dynamic biomarker and indicator of disease progression. (c) 2013 Movement Disorder Society

引用

页码：392 / 395

页数：4

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