A mild Boc deprotection and the importance of a free carboxylate

被引：25

作者：

Thaqi, Ali ^{[2
]}

McCluskey, Adam ^{[1
]}

Scott, Janet L. ^{[2
]}

机构：

[1] Univ Newcastle, Callaghan, NSW 2308, Australia

[2] Monash Univ, Ctr Green Chem, Clayton, Vic 3800, Australia

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 49期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2008.09.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a facile and rapid removal of Boc protecting groups using microwave heating in H2O, With deprotection only requiring a free carboxylic acid group in the starting material. Unlike previous approaches, no additional reagents are required. (C) 2008 Published by Elsevier Ltd.

引用

收藏

页码：6962 / 6964

页数：3

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