Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

被引：52

作者：

Smith, Danielle Westhoff ^{[1
]}

Sugden, Bill ^{[1
]}

机构：

[1] McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USA

来源：

VIRUSES-BASEL | 2013年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer; PROMOTES GENOMIC INSTABILITY; DNA-DAMAGE; OXIDATIVE STRESS; BURKITT-LYMPHOMA; CARCINOMA-CELLS; B-CELLS; LATENT; PROTEIN; EBV; REPLICATION;

D O I：

10.3390/v5010226

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1's role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV.

引用

页码：226 / 240

页数：15

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