Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging

被引：29

作者：

Xiong, Liqin ^{[1
,2
,3
,4
]}

Shen, Bin ^{[1
,2
]}

Behera, Deepak ^{[1
,2
]}

Gambhir, Sanjiv S. ^{[1
,2
]}

Chin, Frederick T. ^{[1
,2
]}

Rao, Jianghong ^{[1
,2
]}

机构：

[1] Stanford Univ, Stanford Mol Imaging Program MIPS, Dept Radiol, Stanford, CA 94305 USA

[2] Stanford Univ, Stanford Mol Imaging Program MIPS, Dept Chem, Stanford, CA 94305 USA

[3] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China

[4] Shanghai Jiao Tong Univ, Dept Nucl Med, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China

来源：

NANOSCALE | 2013年 / 5卷 / 08期

关键词：

UP-CONVERSION; CANCER; F-18; RGD;

D O I：

10.1039/c3nr00335c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a simple, efficient synthesis of novel F-18-labeled imaging agents based on YF3 nanoparticles. Targeting ligands and antitumor drug molecules can be introduced onto the YF3 nanoparticles in a one-pot synthesis. The F-18-labeling reaction proceeds in aqueous solutions at room temperature with excellent radiolabeling yields (>80%) in a very short time (5-10 min). F-18-labeled YF3 nanoparticles displayed high stability in mouse and human serum, and their application for mapping lymph nodes in live rats after local injection has also been demonstrated.

引用

页码：3253 / 3256

页数：4

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