MYC and gastric adenocarcinoma carcinogenesis

被引：88

作者：

Calcagno, Danielle Queiroz

Leal, Mariana Ferreira ^{[1
]}

Assumpcao, Paulo Pimentel ^{[2
]}

Cardoso Smith, Marilia de Arruda ^{[1
]}

Burbano, Rommel Rodriguez ^{[3
]}

机构：

[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Div Genet, BR-04023900 Sao Paulo, Brazil

[2] Fed Univ Para, Joao de Barros Barreto Univ Hosp, BR-66073000 Belem, Para, Brazil

[3] Fed Univ Para, Dept Biol, Lab Citogenet Humana, Inst Ciencias Biol, BR-66075900 Belem, Para, Brazil

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 39期

基金：

巴西圣保罗研究基金会;

关键词：

MYC; Gastric adenocarcinoma; Gastric preneoplastic lesions; Gastric carcinogenesis; Helicobacter pylori;

D O I：

10.3748/wjg.14.5962

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinorna carcinogenesis, including its association with Helicobacterpylori (Hpylorl) and clinical applications. (c) 2008 The WIG Press. All rights reserved.

引用

页码：5962 / 5968

页数：7

共 86 条

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