Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies

被引：22
|
作者：
Sun, Nan [1 ]
Taguchi, Ayumu [2 ]
Hanash, Samir [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA
来源：
JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 12期
关键词：
TGF-beta; targeted therapy; role switch; biomarker; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; SQUAMOUS-CELL CARCINOMA; BREAST-CANCER; SIGNALING PATHWAY; TUMOR-SUPPRESSOR; C-MYC; DISABLED-2; DAB2; MAMMARY-TUMORS; MIR-200; FAMILY;
D O I：
10.3390/jcm5120109
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
TGF-beta induces complicated and even opposite responses in numerous biological processes, e.g., tumor suppression in pre-malignant cells and metastasis promotion in cancer cells. However, the cellular contextual determinants of these different TGF-beta roles remain elusive, and the driver genes triggering the determinants' changes have not been identified. Recently, however, several findings have provided new insights on the contextual determinants of Smads in TGF-beta's biological processes. These novel switches and their effectors may serve as prognostic biomarkers and therapeutic targets of TGF-beta-mediated cancer progression.
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页数：12
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