Insight into the dynamics, localization and magnitude of antigen-specific immune responses by [18F]FLT PET imaging

被引：4

作者：

Aarntzen, Erik H. J. G. ^{[1
,2
]}

Srinivas, Mangala ^{[1
]}

Punt, Cornelius J. A. ^{[2
]}

Figdor, Carl G. ^{[1
]}

Oyen, Wim J. G. ^{[3
]}

de Vries, I. Jolanda M. ^{[1
,2
]}

机构：

[1] RUNMC, Dept Tumor Immunol, Nijmegen, Netherlands

[2] RUNMC, Dept Med Oncol, Nijmegen, Netherlands

[3] RUNMC, Dept Nucl Med, Nijmegen, Netherlands

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 05期

关键词：

cell therapy; cell tracking; F-18]FLT-PET; immunomonitoring; dendritic cell-based vaccines; IN-VIVO;

D O I：

10.4161/onci.19533

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order for cellular therapeutics to succeed, comprehensive monitoring of the transplanted cells in vivo is required i.e., their localization, functionality and numbers in a longitudinal manner. Recently, dendritic cell based vaccines have been monitored by their effect on lymphocyte activation using [F-18]FLT PET in cancer patients.

引用

页码：744 / 745

页数：2

共 6 条

[1] Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3′-fluoro-3′-deoxy-thymidine ([18F]FLT) PET imaging [J].

Aarntzen, Erik H. J. G. ;

Srinivas, Mangala ;

De Wilt, Johannes H. W. ;

Jacobs, Joannes F. M. ;

Lesterhuis, W. Joost ;

Windhorst, Albert D. ;

Troost, Esther G. ;

Bonenkamp, Johannes J. ;

van Rossum, Michelle M. ;

Blokx, Willeke A. M. ;

Mus, Roel D. ;

Boerman, Otto C. ;

Punt, Cornelis J. A. ;

Figdor, Carl G. ;

Oyen, Wim J. G. ;

de Vries, I. Jolanda M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (45) :18396-18399

[2] Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy [J].

de Vries, IJM ;

Lesterhuis, WJ ;

Barentsz, JO ;

Verdijk, P ;

van Krieken, JH ;

Boerman, OC ;

Oyen, WJG ;

Bonenkamp, JJ ;

Boezeman, JB ;

Adema, GJ ;

Bulte, JWM ;

Scheenen, TWJ ;

Punt, CJA ;

Heerschap, A ;

Figdor, CG .

NATURE BIOTECHNOLOGY, 2005, 23 (11) :1407-1413

[3] Dendritic cell immunotherapy: mapping the way [J].

Figdor, CG ;

de Vries, IJM ;

Lesterhuis, WJ ;

Melief, CJM .

NATURE MEDICINE, 2004, 10 (05) :475-480

[4] Imaging proliferation in vivo with [F-18]FLT and positron emission tomography [J].

Shields, AF ;

Grierson, JR ;

Dohmen, BM ;

Machulla, HJ ;

Stayanoff, JC ;

Lawhorn-Crews, JM ;

Obradovich, JE ;

Muzik, O ;

Mangner, TJ .

NATURE MEDICINE, 1998, 4 (11) :1334-1336

[5] Imaging of cellular therapies [J].

Srinivas, M. ;

Aarntzen, E. H. J. G. ;

Bulte, J. W. M. ;

Oyen, W. J. ;

Heerschap, A. ;

de Vries, I. J. M. ;

Figdor, C. G. .

ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (11) :1080-1093

[6] 19F MRI for quantitative in vivo cell tracking [J].

Srinivas, Mangala ;

Heerschap, Arend ;

Ahrens, Eric T. ;

Figdor, Carl G. ;

de Vries, I. Jolanda M. .

TRENDS IN BIOTECHNOLOGY, 2010, 28 (07) :363-370

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