Effect of Food Intake on Hemodynamic Parameters during the Tilt-Table Test in Patients with Postural Orthostatic Tachycardia Syndrome

Background and Purpose The aim of this study was to determine the effect of food intake on the heart rate (HR) in postural orthostatic tachycardia syndrome (POTS). Methods The following five-phase protocol was applied to 41 subjects who had a sustained HR increment of >= 30 beats/min within 10 min of standing in an initial tilt-table test: 1) 10-min supine phase, 2) 10-min 70 degrees-tilted phase, 3) ingestion of 400 mL of Nutridrink Multi Fibre (R), 4) 45-min supine phase, and 5) 10-min 70 degrees-tilted phase. Subjects were divided into four groups: A) difference in HR for standing vs. supine (Delta HR) before the meal of 230 beats/min (n=13), B) Delta HR <30 beats/min before the meal but >= 30 beats/min after the meal (n=12), and C) Delta HR <30 beats/min both before and after the meal (n=16). Group D consisted of 10 healthy subjects. Results Before the meal, Delta HR was significantly higher in group A than in all of the other groups, and in group B than in group D (p<0.001). After the meal, Delta HR was significantly higher in groups A and B (p<0.001 and p<0.0001, respectively). When we pooled patients (according to their symptoms) from group A and B into a POTS group and from group C and D into a non-POTS group, an increase in HR of 25 beats/min before the meal had a sensitivity of 92.0% and a specificity of 80.8%. After the meal, an increase in HR of 30 beats/min had a sensitivity of 96.0% and a specificity of 96.2%. Conclusions Food intake can significantly alter the results of the tilt-table test and so should be taken into account when diagnosing POTS.