Alertenone, a dimer of suberosenone from Alertigorgia sp.

被引：48

作者：

Bokesch, HR ^{[1
]}

Blunt, JW ^{[1
]}

Westergaard, CK ^{[1
]}

Cardellina, JH ^{[1
]}

Johnson, TR ^{[1
]}

Michael, JA ^{[1
]}

McKee, TC ^{[1
]}

Hollingshead, MG ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Lab Drug Discovery Res & Dev,Dev Therapeut Progra, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 04期

关键词：

D O I：

10.1021/np980464z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of organic extracts of the gorgonian Alertigorgia sp. has yielded the previously known suberosenone (1), a cytotoxic tricyclic sesquiterpene of the quadrone class, and alertenone (2), a dimer of suberosenone. The structure of 2 was determined by spectral analysis; the 1D TOCSY experiment was particularly useful in the structure elucidation. Comparison of the in vitro cytotoxicity of alertenone and suberosenone revealed that the dimeric alertenone was devoid of cytotoxicity below 35 mu g/mL. In a hollow-fiber assay model of in vivo activity, suberosenone exhibited some growth inhibition of two of six tumor cell lines tested.

引用

页码：633 / 635

页数：3

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